Reference: Cannabidiol CBD therapy for Schizophrenia, Cannabidiol monotherapy for treatment-resistant schizophrenia
Cannabidiol (CBD), one of the major products of the marijuana plant, is devoid of marijuana’s typical psychological effects. In contrast, potential antipsychotic efficacy has been suggested based on preclinical and clinical data (Zuardi et al., 2002). In this report, we further investigated the efficacy and safety of CBD monotherapy in three patients with treatmentresistant schizophrenia (TRS). This was an in-patient study. All patients were given placebo for the initial 5 days, and from the 6th to 35th day (inclusive) they received CBD (initial oral dose of 40 mg reaching 1280mg/day). On the 36th day, CBD treatment was discontinued and replaced by placebo for 5 days, which was subsequently switched to olanzapine for over 15 days. Efficacy, tolerability and side effects were assessed. One patient showed mild improvement, but two patients didn’t show any improvement during CBD monotherapy. All patients tolerated CBD very well and no side effects were reported. These preliminary data suggest that CBD monotherapy may not be effective for TRS.
Considering the safe profile of CBD administration in humans and laboratory animals, we previously tested CBD in a case study with a 19-year-old schizophrenic female patient who presented serious side effects after treatment with conventional antipsychotics. After a few days of rapidly escalating doses of CBD dissolved in oil, this patient received 1200mg/day of CBD, for 4 weeks. After this period, CBD administration was interrupted and placebo was administered for 4 days.
Cannabidiol CBD therapy for Schizophrenia