Reference: Cannabidiol, CBD and Epilepsy
The case for assessing cannabidiol in epilepsy *Maria Roberta Cilio, †Elizabeth A. Thiele, and ‡Orrin Devinsky
Intractable epilepsies have an extraordinary impact on cognitive and behavioral function and quality of life, and the treatment of seizures represents a challenge and a unique opportunity. Over the past few years, considerable attention has focused on cannabidiol (CBD), the major nonpsychotropic compound of Cannabis sativa. Basic research studies have provided strong evidence for safety and anticonvulsant properties of CBD. However, the lack of pure, pharmacologically active compounds and legal restrictions have prevented clinical research and confined data on efficacy and safety to anecdotal reports. Pure CBD appears to be an ideal candidate among phytocannabinoids as a therapy for treatment-resistant epilepsy. A first step in this direction is to systematically investigate the safety, pharmacokinetics, and interactions of CBD with other antiepileptic drugs and obtain an initial signal regarding efficacy at different dosages. These data can then be used to plan double-blinded placebo-controlled efficacy trials.
Cannabidiol, CBD and Epilepsy an harm the brain, especially during development, and is often associated with cognitive, behavioral, and psychiatric comorbidities that can combine to severely impair quality of life.1,2 Epilepsy onset before age 3 years and pharmacoresistance with uncontrolled seizures are associated with lower IQ later in life.3 In older children and adults, epilepsy is also a serious disorder with comorbidities including stigma, restrictive lifestyle, cognitive and psychiatric disorders, physical injuries, and mortality due to sudden unexpected death, drowning, accident, and suicide.cannabidiol in epilepsy