Cannabidiol Barriers to Research CBD Potential Medical Benefits

Cannabidiol Barriers to Research CBD Potential Medical Benefits
Reference: Nora D. Volkow, M.D., Director, National Institute on Drug Abuse, National Institutes of Health

Cannabidiol Barriers to Research CBD Potential Medical Benefits

Cannabidiol Barriers to Research CBD Potential Medical Benefits. To date, 23 states and the District of Columbia have passed laws allowing marijuana to be used for a variety of medical conditions. Fifteen additional states have enacted laws intended to allow access to CBD oil and/or highCBD strains of marijuana. Interest in the potential therapeutic effects of CBD has been growing rapidly, partially in response to media attention surrounding the use of CBD oil in young children with intractable seizure disorders including Dravet syndrome and LennoxGastaut syndrome. While there are promising preliminary data, the scientific literature is currently insufficient to either prove or disprove the efficacy and safety of CBD in patients with epilepsy.[i] and further clinical evaluation is warranted. In addition to epilepsy, the therapeutic potential of CBD is currently being explored for a number of indications including anxiety disorders, substance use disorders, schizophrenia, cancer, pain, inflammatory diseases and others. My testimony will provide an overview of what the science tells us about the therapeutic potential of CBD and of the ongoing research supported by NIH in this area.

A number of studies over the last two decades or more have reported that CBD has antiseizure activity, reducing the severity of seizures in animal models.[vi],[vii] In addition, there have been a number of case studies and anecdotal reports suggesting that CBD may be effective in treating children with drugresistant epilepsy.[viii],[ix],[x] However, there have only been a few small randomized clinical trials examining the efficacy of CBD as a treatment for epilepsy; the total number of subjects enrolled in these studies was 48. Three of the four studies reported positive results, including decreased frequency of seizures. However, the studies suffered from significant design flaws, including failure to fully quantify baseline seizure frequency, inadequate statistical analysis, and a lack of sufficient detail to adequately evaluate and interpret the findings.viii Therefore, the currently available information is insufficient to draw firm conclusions regarding the efficacy of CBD as a treatment for epilepsy; a recent Cochrane review concluded, there is a need for “a series of properly designed, high quality, and adequately powered trials.”

Cannabidiol Barriers to Research CBD Potential Medical Benefits

 

Cannabidiol Barriers to Research and Potential Medical Benefits